Adam Siepel, Ph.D.

Adam Siepel, Ph.D., is a Professor in the Watson School of Biological Sciences (WSBS) and serves as Chair of the Simons Center for Quantitative Biology (SCQB). Prior to this, Dr. Siepel worked as an associate professor in the department of Biological Statistics and Computational Biology at Cornell University. Dr. Siepel earned his Ph.D. in Computer Science from UC Santa Cruz in 2005. He also holds a B.S degree in Agricultural and Biological Engineering from Cornell University (1994) and a M.S. degree in Computer Science from the University of New Mexico (2001). He joined Cold Spring Harbor Laboratory (CSHL) in 2014.

Dr. Siepel has authored nearly 100 peer-reviewed publications. He has served on the editorial boards for Genome Research and PLOS Computational Biology, on review panels for the National Science Foundation and the National Institutes of Health, and on advisory committees for the National Science Foundation CAREER Award, and a Sloan Research Fellowship. Dr. Siepel is also an affiliate member of the New York Genome Center (NYGC) where he co-chairs a new NYGC Working Group on Population Genomics.

Current Lab Members

Katie Brenner

QB Science Manager

Irene Gill

Assistant to the Chair

Melissa Hubisz

Ph.D. Student

Elizabeth Hutton

Ph.D. Student

Adrian Platts

Research Associate

Ritika Ramani

Computation Science Developer II

Lab Alumni

Yi-Fei Huang (Postdoc, 2015–2018). Novel statistical models to study the mechanisms of evolution and gene expression. Yi-fei is currently an Assistant Professor in the Department of Biology and the Huck Institute of the Life Sciences at Pennsylvania State University.

Leonardo Arbiza (Postdoc, 2010–2013). Natural selection on transcription factor binding sites in recent human evolution. Leo was a joint postdoc between the Siepel and Keinan Labs at Cornell, with a focus on X-vs.-autosome genetic variation.  Leonardo is currently a Computational Biology Research Scientist at Twist Bioscience, a startup company that has revolutionized massive high quality DNA synthesis.

Bronislava Brejova (Postdoc, 2006–2008). Comparative genomic methods for gene prediction. Brona is now an associate professor in the Department of Computer Science at Comenius University in Bratislava, Slovakia.

Sang Chul Choi (Postdoc, 2010–2013). Comparative genomics and transcriptomics of Streptococcus species. Sang Chul collaborated with Mike Stanhope at Cornell and Robert Burne at the University of Florida on various comparative and functional genomic analyses of pathogenic Streptococci. Sang Chul is currently in the Department of Biotechnology at Sungshin Women’s University, Seoul, Republic of Korea.

Omar Cornejo (Postdoc, 2009–2010). Population genetics of Streptococcus species. Omar contributed to a joint project involving the Siepel, Bustamante, and Stanhope labs before finishing his postdoc with Carlos Bustamante at Stanford. Omar is now an assistant professor of biology at Washington State University.

Charles Danko (Postdoc, 2009–2014). Computational and experimental research in transcriptional regulation, including estimation of transcription rates, prediction of enhancers, and comparative genomics of gene regulation in primates. Charles is now an assistant professor at the Baker Institute for Animal Health and the Department of Biomedical Sciences at Cornell. He continues to work with the Siepel and Lis Labs on analyses of GRO-seq and PRO-seq data.

Ilan Gronau (Postdoc, 2009–2014). Development of coalescent-based methods for demography inference (G-PhoCS) and probabilistic methods for measuring the influence of natural selection on dispersed genomic elements (INSIGHT). Ilan is now a senior lecturer at the School of Computer Science in the Interdisciplinary Center (IDC), Herzliya, Israel. He continues to collaborate with the Siepel Lab from Israel.

Brad Gulko (Ph.D. Student, 2010–2017). Developed a novel Bayesian scoring system for identifying combinations of functional genomic assay results that pinpoint genomic positions with identifiable fitness consequence (“fitCons” scores). Brad is now a staff engineer at

Carolin Kosiol (Postdoc, 2006–2008). Comparative genomics of mammals, including positive selection in primates. Carolin is currently a Lecturer in Bioinformatics at the School of Biology, University of St. Andrews, Fife, UK.

Andre L. Martins (Ph.D. student, 2007–2014). Bioinformatic analysis of transcriptional regulation in mammals and Drosophila, in close collaboration with the Lis Lab. Andre has returned to his native Portugal and is working in software development.

Jaaved Mohammed (Ph.D. student, 2009–2016). Molecular evolution of miRNAs in Drosophila. Jaaved was a joint member of the Siepel Lab and Eric Lai’s Laboratory at Memorial Sloan Kettering Cancer Center. He is now a postdoc with Joanna Wysocka at Stanford.

Lenore Pipes (Ph.D. student, 2012-2017). Evolution of alternative splicing in primates. Lenore was a joint member of the Siepel Lab and Christopher Mason’s Laboratory at Cornell University. She is now a postdoc with Rasmus Nielsen at UC Berkeley.

Matthew Rasmussen (Postdoc, 2011–2013). Genome-wide inference of ancestral recombination graphs. Matt is now a software engineer at Counsyl, Inc. in South San Francisco.  Occasionally, we still lure him into thinking about ancestral recombination graphs for old times’ sake.

Tomas Vinar (Postdoc, 2006–2008). Probabilistic models of gene cluster evolution. Tomas is now an associate professor in the Department of Applied Informatics at Comenius University in Bratislava, Slovakia.

Other Alumni

Master’s students

Adam Diehl, Michael D. Phillips

Undergraduate researchers

Alexandra Denby, Tytus Mak, Alison Marklein, Joseph Porter, Renee Setter, and Daniel Sussman.